Doctor of Internal Medicine
The history of acetylsalicylic acid: use and transformations of an ancient drug
Acetylsalicylic acid (ASA) is an example of a molecule that is still largely used in spite of the over 120 years passed since its chemical synthesis. Evidence of the therapeutic use of salicylates dates back to the times of the ancient Egyptians. It is a story full of discoveries culminated with the Nobel Prize to Sir John R.Vane. Today ASA is one of the most studied active substances and the topic of many publications in high scientific level journals. The pharmacological effect of acetylsalicylic acid (ASA) that has success and attention in modern times is certainly its positive interaction with the risk and prognosis of cardiovascular diseases. Today, the vascular protection properties of ASA are significant also in patients who undergo coronary angioplasty with the introduction of stent, which represent the reference treatment for acute coronary syndrome patients and whose effectiveness over time depends on the basic action of this active substance, which has been proved to be effective in a wide population.