Twenty-three years after Dolly: how should cloning technology be used?
The motives guiding the development of animal cloning technology were animal husbandry related and designed to obtain copies of animals of high genetic value or whose phenotype was known. This goal is still a valid one. All or nearly all mammals have been successfully cloned and cloning has turned out to be a potent base research tool with which to study genome reprogramming. The biological opportunities and limits of the technique – still to be perfected – have shifted attention in the direction of cloning to generate animal models in both animal husbandry and medical fields, integrating cloning with genetic engineering and genome editing.