TOMAS LINDAHL

BETWEEN THE THIRD AND THE FOURTH EDITION –  OCTOBER 2nd, 2017

18.00 – AULA ABSIDALE DI SANTA LUCIA

Nobel lecture – DNA INSTABILITY AND THE ROLE OF TREX1

TOMAS LINDAHL


chairperson: Lucio Ildebrando Maria Cocco


The covalent structure of DNA is less stable under physiological conditions than has been generally assumed. For this reason endogenous damage to DNA is continuously repaired under in vivo conditions. We have discovered and characterised several of the enzymes that account for these essential processes. The nuclear exonuclease TREX1 removes unwanted single stranded DNA fragments in mammalian cells and counteracts autoimmunity.